Major Vault Protein is Expressed along the Nucleus-Neurite Axis and Associates with mRNAs in Cortical Neurons
نویسندگان
چکیده
منابع مشابه
Major vault protein is expressed along the nucleus-neurite axis and associates with mRNAs in cortical neurons.
Major Vault Protein (MVP), the main constituent of the vault ribonucleoprotein particle, is highly conserved in eukaryotic cells and upregulated in a variety of tumors. Vaults have been speculated to function as cargo transporters in several cell lines, yet no work to date has characterized the protein in neurons. Here we first describe the cellular and subcellular expression of MVP in primate ...
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Despite their ubiquitous expression and high conservation during evolution, precise cellular functions of vault ribonucleoparticles, mainly built of multiple major vault protein (MVP) copies, are still enigmatic. With regard to cancer, vaults were shown to be upregulated during drug resistance development as well as malignant transformation and progression. Such in a previous study we demonstra...
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Introduction The 110 kDa major vault protein (MVP) represents the main component of evolutionary highly conserved ribonucleoprotein particles called vaults and accounts for 70% of the total particle mass (Mossink et al., 2003). Vaults are barrel-shaped structures with a hollow interior. They are composed of multiple copies of three proteins and small, untranslated vault RNAs. Vaults were found ...
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ژورنال
عنوان ژورنال: Cerebral Cortex
سال: 2008
ISSN: 1047-3211,1460-2199
DOI: 10.1093/cercor/bhn203